Linda Levin, DDS, PhD
UNC-CH School of Dentistry
Sunday, February 3, 2013
International Academy of Endodontics, Annual Meeting
The Fairmont Hotel
“Pathophysiology of Resorption"
Resorption is a normal physiologic process in bone that is crucial for the integrity, maintenance, healing and adaptation of that tissue. In teeth however, the only resorption considered physiologic is that seen during exfoliation of the primary denti- tion. Pathologic root resorption has multiple classifications based on initiating/propagating factors. Identification of these factors is the basis for successful therapeutic intervention. Dental trauma is the most common cause of root resorption but there are other classifications of resorption for which the etiology is unclear. Host and pathogen derived mediators that drive or potentiate the resorptive process have been identified. This presentation will review what is known about the molecu- lar and cellular contributions to root resorption and their impli- cations regarding successful clinical therapies.
Attendees will learn:
1. The molecular and cellular mechanisms of resorption.
2. The mode of action of clinical antiresorptive therapies in dentistry.
3. Why ECIR is different from other types of resorption.
4. Models for the study of External Cervical Invasive Resorption.